M178. Computational Systems Biology: Modeling and Simulation of Biological Systems
(Same as Bioengineering CM186, Computational and Systems Biology M186, and Computer Science CM186.) Lecture, four hours; laboratory, two hours; discussion, one hour. Requisites: Life Sciences 30A, 30B, Mathematics 32A or M32T, 33A, and 33B, or Mathematics 3A, 3B, and 3C, or Mathematics 31A, 31B, 32A or M32T, 33A, and 33B. Dynamic biosystem modeling and computer simulation methods for studying analyzing biological/biomedical processes and systems at multiple levels of organization. Intermediate linear and nonlinear control system, multicompartmental, epidemiological, pharmacokinetic, and other biomodeling methods applied to life sciences problems at molecular, cellular, organ, and population levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into dynamical mathematical models, and implementing them for simulation, quantification, and analysis. Numerical simulation, optimization, and parameter identifiability and search algorithms, with model discrimination and analysis and software exercises in PC laboratory assignments. Letter grading.