• M202. Advanced Topics in Cryogenic Electron Microscopy

    Units: 3.0

    (Same as Biological Chemistry M202.) Lecture, two hours; discussion, one hour. Students master advanced topics in membrane protein biology, and learn both theory and practice of cryogenic electron microscopy (cryo-EM) as emerging technology in structural biology. Cryo-EM methodologies covered include cryotomography, single particle reconstruction, electron crystallography, and microcrystal electron diffraction. Letter grading.

  • 235. Rigor and Reproducibility

    Units: 2.0

    Lecture, one hour; discussion, one hour. Two cornerstones of science advancement are rigor in designing and performing scientific research and ability to reproduce biomedical research findings. Applications of rigor ensures robust and unbiased experimental design, methodology, analysis, interpretation, and reporting of results. When results can be reproduced by multiple scientists, it validates original results and readiness to progress to next phase of research. Scientific rigor is strict application of scientific method to ensure unbiased and well-controlled experimental design, methodology, analysis, interpretation, and reporting of results. Covers literature and videos on rigor and reproducibility in biomedical research. Discussion of issues raised by lecture, or case-studies, with training program faculty. Students learn that reproducibility is common problem in biomedical research and how to improve it. S/U grading.

  • 252. Writing for Science

    Units: 1.0

    Seminar, one hour. Corequisite: Biological Chemistry 251A or 251B or 251C. Limited to first-year Molecular Biology PhD students. Development of specific skills in scientific writing within context of one advanced course on mechanics of gene transcription. Letter grading.

  • 254A. Concepts in Molecular Biosciences

    Units: 3.0

    Lecture, three hours; discussion, two hours. Limited to human genetics and molecular biology graduate students. Five-week course covering four basic experimental approaches of biochemistry and molecular biology in context of various specific topics, including (1) structural biology, with protein and nucleic acid structure and molecular recognition, (2) use of cell-free and purified in vitro systems to dissect reaction mechanisms, (3) biochemical approaches to dissecting complex reactions/pathways in cells, and (4) enzymology and protein chemistry. Letter grading.

  • 254B. Concepts in Molecular Biosciences

    Units: 3.0

    Five-week course. Lecture, three hours; discussion, two hours. Enforced requisite: course 254A. Important biological problems that have been genetically analyzed in different organisms or small number of related problems. Major genetic approaches used in relevant organisms, including both forward and reverse genetic approaches, genetic interactions between genes (genetic enhancers and suppressors), transgenic technology, and systematic genomic strategies. Letter grading.

  • 254C. Concepts in Molecular Biosciences

    Units: 3.0

    Five-week course. Lecture, three hours; discussion, two hours. Enforced requisites: courses 254A, 254B. Molecular mechanisms underlying complex problems in cell biology. Experimental approaches used to define mechanisms involved in protein targeting, cell structure and subcellular organization, cell communication, and intracellular signaling. Analysis of pathways that connect these cellular processes. Letter grading.

  • 254D. Concepts in Molecular Biosciences

    Units: 3.0

    Five-week course. Lecture, three hours; discussion, two hours. Enforced requisites: courses 254A, 254B, 254C. Application of biochemical, molecular biological, genetic, and cell biological approaches to understand specialized topics in life and biomedical sciences, including developmental disease, stem cell biology, synaptic transmission in nervous system, cancer, and heart disease. Letter grading.

  • 255. Scientific Writing

    Units: 3.0

    Lecture, two hours; discussion, one hour. Limited to first-year Molecular Biology PhD students. Improvement of academic literacy through development of specific skills in scientific writing. Review of principles of effective writing using practical examples and exercises. Topics include principles of good writing, tricks for writing faster and with less anxiety, format of scientific manuscripts, art of editing, and issues in publication and peer review. Letter grading.

  • 298. Current Topics in Molecular Biology

    Units: 2.0

    Student presentation/seminar, two hours. Students present oral critiques and participate in discussions on assigned topics. S/U grading.

  • 300. Entering Mentoring Training Program

    Units: 1.0

    Seminar/discussion, 90 minutes. Limited to 25 graduate students. Offers formal training on effective mentoring of undergraduate students in science laboratories. Priority given to those who either have prior experience as mentor or are currently mentoring undergraduates; however, all are encouraged. Exploration of mentoring strategies through lecture, collaborative learning, and case studies. Topics include maintaining effective communication, aligning expectations, addressing equity and inclusion, fostering independence, cultivating ethical behavior, and articulating mentoring philosophy. S/U grading.

  • 497. Career Readiness Inside and Outside Academy

    Units: 2.0

    Seminar, 90 minutes. Limited to 25 graduate students. Preparation for and exploration of career options inside and beyond academia. Performance of targeted career research, practicing of rofessional conduct and communication, and exp loration of nuances of diverse workplaces. S/U grading.

  • 596. Directed Individual Studies

    Units: 2.0 to 12.0

    Tutorial, to be arranged. Directed individual research or study. May be repeated for maximum of 12 units. S/U grading.

  • 599. PhD Dissertation Research and Writing

    Units: 2.0 to 12.0

    Tutorial, to be arranged. Directed individual studies for students who have advanced to candidacy. May be repeated for maximum of 12 units. S/U grading.