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    Microbiology, Immunology, and Molecular Genetics

Microbiology, Immunology, and Molecular Genetics Course Listings

Lower Division Courses

5. Science of Memory and Learning. (4) Lecture, seven hours. Nature of intelligence, overview of brain structure, study of memory systems, including memory retrieval, context of memories with emotion, sleep, and memory. Survey of metacognition and performance of learning. Offered in summer only. P/NP or letter grading.

6. Microbiology for Nonmajors. (4) Lecture, four hours. Not open for credit to students with credit for course 101. Designed for nonscience students; introduction to biology of microorganisms (bacteria, viruses, protozoa, algae, fungi), their significance as model systems for understanding fundamental cellular processes, and their role in human affairs. P/NP or letter grading.

7. Developments in Biotechnology. (4) Lecture, three hours; demonstration/laboratory, one hour. Recommended preparation: course 6 or Life Sciences 2. Not open for credit to students with credit for course 101 or Life Sciences 3. Survey of recent developments in biotechnology, with emphasis on use of single-celled organisms. Review of basic principles of microbiology as they apply to biotechnology and examination of wide variety of topics, including alternate energy sources, pollution, cleanup, genetic fingerprinting, genetic engineering, and agricultural and food microbiology. P/NP or letter grading.

10. Medical Microbiology for Nursing Students. (4) Lecture, three hours; discussion, one hour. Requisite: Mathematics 3A or 31A. Limited to Nursing majors. Introduction to biology of microbial pathogens, their role in development of human immune response, and presentation of symptoms and disease caused by microbial infections. Letter grading.

12. Biological Threats to Society: Bioterrorism and Emerging Infections. (4) Lecture, four hours. Examination of biological threats to American society. Coverage of biological weapons going back to first attempts to use microbes or toxins as weapons, and of emerging infections. Introduction to basic biology to understand infectious disease. P/NP or letter grading.

20. Prenursing Medical Microbiology. (4) Lecture, four hours; discussion, one hour. Requisite: Mathematics 3A or 31A. Investigation of medical microbiological life, with emphasis on bacterial pathogens from host, as well as pathogen, perspective. Role of pathogens in development of human immune response, presentation of symptoms and disease caused by microbial infections, and diagnosis and treatment of microbial infections. Offered in summer only. Letter grading.

Upper Division Courses

100L. Microbiology Laboratory for Professional Schools. (3) Lecture, two hours; laboratory, three hours. Requisites: Life Sciences 3, 4, with grades of C or better. Recommended corequisite: course 101. Limited to nonmajors. Experimental techniques of microbiology, with emphasis on cultivation and characterization of bacteria. Laboratory exercises include light microscopy, quantitative techniques, and identification methods. Students learn to work effectively in groups to perform experiments, record observations, and analyze results. Letter grading.

101. Introductory Microbiology. (4) Lecture, three hours; discussion, one hour. Requisites: Life Sciences 3, 4. Historical foundations of microbiology; introduction to bacterial structure, physiology, biochemistry, genetics, and ecology. Letter grading.

102. Introductory Virology. (4) Lecture, three hours; discussion, one hour. Requisite: Life Sciences 3 with grade of C- or better. Biological properties of bacterial and animal viruses, replication, methods of detection, interactions with host cells and multicellular hosts. Letter grading.

103AL. Research Immersion Laboratory in Virology. (5) (Formerly numbered 103L.) Lecture, two and one half hours; laboratory, eight hours. Requisites: Life Sciences 3, 4, 23L. Recommended requisite or corequisite: course 101. Course 103AL is enforced requisite to 103BL. Limited to Microbiology, Immunology, and Molecular Genetics and Molecular, Cell, and Developmental Biology majors. Research-oriented laboratory experience designed to promote discovery of novel bacterial viruses (phages). Working in teams, students conduct research projects that incorporate techniques in microbiology, virology, and molecular biology and involve use of bioinformatics tools and computational analysis software. Emphasis on reading and understanding scientific literature as well as improving critical thinking skills such as ability to evaluate hypotheses or experimentally address scientific questions. Critical aspects of research process, including record keeping, ethics, laboratory safety and citizenry, mechanics of scientific writing, and project responsibilities and ownership. Letter grading.

103BL. Advanced Research Analysis in Virology. (4) (Formerly numbered 188C.) Laboratory, six hours. Enforced requisite: course 103AL. Limited to Microbiology, Immunology, and Molecular Genetics and Molecular, Cell, and Developmental Biology majors. Designed to provide students authentic, discovery-based research experience in life sciences. Investigation to be primarily computational in nature whereby students use bioinformatics or mathematical modeling software to interpret, expand, or refine datasets. Use of graphics software to prepare figures and illustrations for presentations, posters, reports, and websites (database entries). Research accomplishments discussed in weekly seminar-style meetings in which student groups create PowerPoint slides and formally present results to class. Production of team poster and final report describing entire research project required. Letter grading.

105. Biological Microscopy. (4) Lecture, four hours; laboratory, three hours (five weeks only). Requisite or corequisite: Physics 1C or 6C. Introduction to modern microscopy technologies used in biochemistry, medicine, microbiology, and nano research. Basic image formation principles of microscopy, methods for sample preparation, imaging, data acquisitions, and three-dimensional reconstruction and visualization. Fluoresce, confocal, and super-resolution light microscopy; transmission electron microscopy, electron tomography, and three-dimensional cryo-electron microscopy; and atomic force and other scanning probe microscopy modalities. Practical experience in research provided through five carefully designed electron microscopy laboratory modules. P/NP or letter grading.

106. Molecular and Genetic Basis of Bacterial Infections. (4) Lecture, three hours; discussion, one hour. Requisite: course 101. Biochemical and genetic properties of bacteria that afford potential for pathogenicity. Epidemiology and transmission of disease; chemotherapy and drug resistance. Regulation of virulence factors. Letter grading.

107. Viral Pathogenesis. (4) Lecture, three hours; discussion, one hour. Requisites: course 185A, Chemistry 153A. Viral pathogens that infect mammals. Viral entry into and replication in host cells. Host response and host/virus interaction. Pathogenic manifestations exhibited during viral infections. Letter grading.

109AL. Research Immersion Laboratory in Microbiology. (5) Lecture, three hours; laboratory, eight hours. Requisites: Life Sciences 3, 4, 23L. Recommended requisite or corequisite: course 101. Course 109AL is enforced requisite to 109BL. Limited to Microbiology, Immunology, and Molecular Genetics premajors and majors and Molecular, Cell, and Developmental Biology majors. Research-oriented laboratory experience designed to promote discovery of novel microorganisms. Working in teams, students conduct research projects that incorporate techniques in microbiology and molecular biology and involve use of bioinformatics tools and phylogenetics software for data analysis. Emphasis on reading and understanding scientific literature as well as improving critical thinking skills such as ability to create and evaluate hypotheses or experimentally address scientific questions. Critical aspects of research process, including record keeping, ethics, laboratory safety and citizenry, mechanics of scientific writing, and project responsibilities and ownership. Letter grading.

109BL. Advanced Research Analysis in Microbiology. (4) Laboratory, six hours. Enforced requisite: course 109AL. Limited to Microbiology, Immunology, and Molecular Genetics premajors and majors and Molecular, Cell, and Developmental Biology majors. Designed to provide students authentic, discovery-based research experience in life sciences. Investigation to be primarily computational in nature whereby students use bioinformatics or mathematical modeling software to interpret, expand, or refine datasets. Use of graphics software to prepare figures and illustrations for presentations, posters, reports, and websites (database entries). Research accomplishments discussed in weekly seminar-style meetings in which student groups create PowerPoint slides and formally present results to class. Production of team poster and final report describing entire research project required. Letter grading.

CM122. Mouse Molecular Genetics. (2) (Same as Human Genetics CM122.) Lecture, two hours. Requisites: course CM156, Life Sciences 4. Emphasis on use of mouse genetic approach to studying fundamental biological questions. Topics include mouse genome and functional genomics, mutagenesis screening and cloning of disease genes, transgenesis and its application in developmental biology, stem cell biology, neurobiology, and modeling human genetic disorders. Reading materials include original papers and reviews. Concurrently scheduled with course CM222. P/NP or letter grading.

123. Advanced Annotation and Comparative Genomics. (4) Lecture, two and one half hours; computer laboratory, six hours. Requisite: course 103AL or Molecular, Cell, and Developmental Biology 187AL with grade of B- or better. Participation in discovery-based research experience, working as research team to analyze microbial genomes using bioinformatics techniques involving variety of online databases. Investigation of cellular pathways and structures as means to discover novel genes and unusual variations in classical systems. Results of high-quality annotation efforts may lead to publication in peer-reviewed science journal. Part of DOE Joint Genome Institute Undergraduate Research in Microbial Genome Annotation education program. Offered in summer only. Letter grading.

132. Cell Biology of Nucleus. (4) Lecture, three hours; discussion, one hour. Requisite: Life Sciences 4. Cell biology of eukaryotic nucleus, including principles of chromosome structure, transcription, RNA processing, nuclear-cytoplasmic transport, and cell cycle control. Letter grading.

C134. Ethics and Accountability in Biomedical Research. (2) Seminar, two hours. Designed for graduate students and undergraduates who have credit for life sciences or biomedical individual studies 199 course. Responsibilities and ethical conduct of investigators in research, data management, mentorship, grant applications, and publications. Responsibilities to peers, sponsoring institutions, and society. Conflicts of interest, disclosure, animal subject welfare, human subject protection, and areas in which investigational goals and certain societal values may conflict. Concurrently scheduled with course C234. P/NP grading.

CM156. Human Genetics and Genomics. (4) (Same as Molecular, Cell, and Developmental Biology CM156.) Lecture, three hours; discussion, two hours. Requisites: Life Sciences 3, 4. Application of genetic principles in human populations, with emphasis on genomics, family studies, positional cloning, Mendelian and common diseases, cancer genetics, animal models, cytogenetics, pharmacogenetics, population genetics, and genetic counseling. Lectures and readings in literature, with focus on current questions in fields of medical and human genetics and methodologies appropriate to answer such questions. Concurrently scheduled with course CM256. Letter grading.

158. Microbial Genomics. (4) Lecture, three hours; discussion, one hour. Requisites: course 101, Chemistry 153A. Evolution, biodiversity, and sequencing of genomes; bacterial and viral genomes; bioenergetics; gene knockouts; genomics of antibiotic resistance; proteomics. Guest lecturers from department and related departments who discuss key papers with focus on their areas of expertise. Letter grading.

168. Molecular Parasitology. (4) Lecture, three hours; discussion, one hour. Requisites: Life Sciences 3, 4. Survey of parasitic protozoa not only as parasites that interact with host, but also as model systems for analysis of basic biological phenomena such as gene regulation, molecular development, cell-cell interactions, molecular evolution, and novel biochemical pathways. Letter grading.

C174. Advanced Topics in Molecular Parasitology. (2) Lecture, two hours. Requisites: course 168, Life Sciences 3, 4. Examination of recent advances in molecular biology of parasites and host/parasite relationship. Specific topics include parasite development, antigenic variation in trypanosomes, RNA editing, prospects for parasitic vaccines. Concurrently scheduled with course C274. Letter grading.

180A. Scientific Analysis and Communication I. (2) Seminar, two hours. Enforced corequisite: course 196A. Students read and discuss scientific articles and give presentations, introducing research topics using relevant primary literature. Critical aspects of research process, including record keeping, ethics, laboratory safety and citizenry, mechanics of scientific writing, diverse approaches to research, and project responsibilities and ownership. Acquisition of in-depth and broad knowledge about student research projects, improvement of oral and written communication skills, and full appreciation of process of doing good science and becoming skilled researchers. Letter grading.

180B. Scientific Analysis and Communication II. (2) Seminar, two hours. Enforced requisite: course 180A. Enforced corequisite: course 196B. Students give presentations similar to laboratory meeting or research symposium talk in which speakers discuss project goals, methodological approaches, results, and conclusions. How to write research papers as well as prepare and present scientific posters. Production of deliverables that demonstrate research achievements and creation of sense of pride for work accomplished as skilled researchers. Letter grading.

185A. Immunology. (5) Lecture, three hours; discussion, 90 minutes. Requisites: Life Sciences 3, 4, 23L. Recommended requisite or corequisite: Chemistry 153A. Not open for credit to students with credit for course 261. Introduction to experimental immunobiology and immunochemistry; cellular and molecular aspects of humoral and cellular immune reactions. Letter grading.

188A. Special Courses in Microbiology, Immunology, and Molecular Genetics. (4) (Formerly numbered 188.) Seminar, four hours. Enforced requisites: Life Sciences 3, 4. Departmentally sponsored experimental or temporary courses, such as those taught by visiting faculty members. May be repeated for credit with topic change. P/NP or letter grading.

188B. Special Courses in Microbiology, Immunology, and Molecular Genetics. (2) Seminar, two hours. Enforced requisite: Life Sciences 3. Departmentally sponsored experimental or temporary courses, such as those taught by visiting faculty members. May be repeated for credit with topic change. Letter grading.

191H. Honors Research Seminars: Microbiology, Immunology, and Molecular Genetics. (2) Seminar, two hours. Requisite or corequisite: course 198A or 198B or 198C. Limited to senior microbiology, immunology, and molecular genetics honors program students. Discussion of current research literature, with focus on thesis topics/areas that students are working on as part of departmental honors requirements. One-hour presentation of student thesis research and current literature associated with it required. May be repeated for credit. Letter grading.

193A. Journal Club Seminars: Microbiology, Immunology, and Molecular Genetics. (1) Seminar, one hour. Limited to undergraduate students. Discussion of readings selected from current literature in microbiology, immunology, and molecular genetics field. P/NP grading.

193B. Journal Club Seminars: Microbiology, Immunology, and Molecular Genetics. (1) Seminar, one hour. Limited to undergraduate students. Discussion of readings selected from current literature in microbiology, immunology, and molecular genetics. Letter grading.

194A. Research Group Seminars: Microbiology, Immunology, and Molecular Genetics. (1) Seminar, one hour. Designed for undergraduate students who are part of research group in department faculty laboratory. Discussion of research methods and current literature in field or of research of faculty members or students. May be repeated for credit. P/NP grading.

194B. Research Group Seminars: UC LEADS and NIH/MARC. (2) Seminar, two hours. Limited to students in UC LEADS and NIH/MARC programs. Analysis, review, and critique of current papers in biomedical sciences disciplines, using skills necessary for effective oral communication and effective use of software such as PowerPoint for oral presentations. May be repeated for credit. Letter grading.

196A. Research Apprenticeship I in Microbiology, Immunology, and Molecular Genetics. (4) (Formerly numbered 199A.) Tutorial, 12 hours. Enforced requisites: Life Sciences 3, 4, 23L, 3.0 premajor and/or major grade-point average, and at least one term of prior experience in same laboratory in which 196A research is to be conducted. Enforced corequisite: course 180A. Course 196A is enforced requisite to 196B. Designed for undergraduate students who are interested in pursuing inquiry-based and hypothesis-driven research experience in laboratory of departmental faculty mentor. Guided research course to be taken in conjunction with course 180A, followed by continuation research course 196B. Technical aspects vary depending on specific laboratory; however, all students learn how to apply scientific method: propose hypothesis, identify experiments to address hypothesis, perform experiments, and analyze results. How to record information from experimental activities into laboratory notebooks and to write research proposals. Letter grading.

196B. Research Apprenticeship II in Microbiology, Immunology, and Molecular Genetics. (4) (Formerly numbered 199B.) Tutorial, 12 hours. Enforced requisite: course 196A. Enforced corequisite: course 180B. Expansion of scope, increasing depth, and implementation of independence in research to be performed in same laboratory as course 196A to facilitate learning and implementation of goals stated previously. Technical aspects vary depending on specific laboratory; however, all students use scientific method learned in course 196A and continue same experimental scope proposed, but with additional degree of independence in technical and intellectual aspects of research. Letter grading.

197. Individual Studies in Microbiology, Immunology, and Molecular Genetics. (2 to 4) Tutorial, four hours. Limited to juniors/seniors. Individual intensive study, with scheduled meetings to be arranged between faculty member and student. Assigned reading and tangible evidence of mastery of subject matter required. May be repeated for credit. Individual contract required. P/NP or letter grading.

198A-198B-198C. Honors Research in Microbiology, Immunology, and Molecular Genetics. (4-4-4) Tutorial, 12 hours. Course 198A is requisite to 198B, which is requisite to 198C. Limited to junior/senior microbiology, immunology, and molecular genetics honors program students. Directed individual research for departmental honors; students must have faculty sponsor. Progress report must be submitted to faculty sponsor at end of each of first two terms, with honors thesis submitted at end of final term. Maximum of 8 units may be applied toward major, with balance applied toward B.S. degree requirements. Individual contract required. Letter grading.

199. Directed Research in Microbiology, Immunology, and Molecular Genetics. (4) (Formerly numbered 199A.) Tutorial, 12 hours. Preparation: minimum 2.5 grade-point average in premajor and major. Supervised individual research project under guidance of departmental faculty mentor. Copy of report describing research must be filed with Student Affairs Office by end of term. May be repeated for credit. Individual contract required. Letter grading.

Graduate Courses

208. Molecular Biology of Animal Viruses. (4) Lecture, three hours. Preparation: courses in general biochemistry and general microbiology, including virology. Recommended for advanced undergraduate students with majors in public health, biology, or microbiology and for graduate students with interest in any field of biology or chemistry. Overview of animal viruses, including viral structure, virus cell interaction, virus replication, and viral oncogenesis. Special emphasis on understanding molecular mechanism involved in control and regulation of replication, transcription, and translation of viral genome and its complex interaction with host. Letter grading.

CM222. Mouse Molecular Genetics. (2) (Same as Human Genetics CM222.) Lecture, two hours. Requisites: course CM256, Life Sciences 4. Emphasis on use of mouse genetic approach to studying fundamental biological questions. Topics include mouse genome and functional genomics, mutagenesis screening and cloning of disease genes, transgenesis and its application in developmental biology, stem cell biology, neurobiology, and modeling human genetic disorders. Reading materials include original papers and reviews. Concurrently scheduled with course CM122. S/U or letter grading.

M229. Molecular Mechanisms of Host/Pathogen Interaction. (4) (Same as Pathology M229.) Lecture, two hours; discussion, two hours. Requisites: Biological Chemistry 254A through 254D. Molecular mechanisms of microbial interactions with eukaryotic host cells that result in disease or pathogen survival. Topics include pathogenesis of common viruses, bacteria, fungi, and parasites, basis of toxin-mediated cellular damage, and immune suppression of microbial tissue damage. Letter grading.

C234. Ethics and Accountability in Biomedical Research. (2) Seminar, two hours. Designed for graduate students and undergraduates who have credit for life sciences or biomedical individual studies 199 course. Responsibilities and ethical conduct of investigators in research, data management, mentorship, grant applications, and publications. Responsibilities to peers, sponsoring institutions, and society. Conflicts of interest, disclosure, animal subject welfare, human subject protection, and areas in which investigational goals and certain societal values may conflict. Concurrently scheduled with course C134. S/U grading.

M240. Cytokines and Reproductive Biology. (2) (Same as Molecular, Cell, and Developmental Biology M240.) Lecture, 90 minutes; discussion, one hour. Overview of current progress on research in cytokines and other immune system molecules in reproductive biology. S/U or letter grading.

242. Seminar: Microbial Molecular Genetics. (2) Seminar, two hours. Student and instructor presentations and critical discussion of newly emerging concepts in prokaryotic and/or eukaryotic molecular genetics. Emphasis on nature of the gene and control of gene expression. May be repeated for credit. S/U or letter grading.

244. Research Ethics Seminar. (2) Seminar, two hours. Designed for students supported by UCLA Predoctoral Training Program in Genetic Mechanisms and required of all trainees in two of their three years of support. Examination of prominent cases of scientific fraud through analysis and formal discussion. Faculty and students from School of Law may be invited to participate. S/U grading.

250. Seminar: Microbial Metabolism. (2) Seminar, two hours. Discussion and student presentations of recent work in areas of genetic regulation and physiology of bacterial metabolism. S/U or letter grading.

CM256. Human Genetics and Genomics. (4) (Same as Molecular, Cell, and Developmental Biology CM256.) Lecture, three hours; discussion, two hours. Requisites: Life Sciences 3, 4. Application of genetic principles in human populations, with emphasis on genomics, family studies, positional cloning, Mendelian and common diseases, cancer genetics, animal models, cytogenetics, pharmacogenetics, population genetics, and genetic counseling. Lectures and readings in literature, with focus on current questions in fields of medical and human genetics and methodologies appropriate to answer such questions. Concurrently scheduled with course CM156. Independent research project required of graduate students. Letter grading.

261. Molecular and Cellular Immunology. (4) Lecture, four hours. Requisites: Biological Chemistry 254A through 254D. Strongly recommended corequisite: course 298. Comprehensive course for graduate students and selected undergraduate students covering fundamentals and recent advances in molecular and cellular immunology. Lectures supplemented by course 298 seminar, with focus on reading and analysis of primary research articles. Oral presentation required. S/U or letter grading.

262A-262B-262C. Seminars: Current Topics in Immunobiology of Cancer. (2-2-2) Seminar, two hours. Designed for graduate students (or undergraduate students with consent of instructor). Review of recent literature in immunology, biology, and biochemistry of cancer, with emphasis on fundamental studies involving cell-mediated immunity, humoral response, tumor specific antigens, and new techniques. Discussion of reports on scientific meetings. Each course may be repeated for credit. S/U or letter grading.

270. Seminar: Molecular Virology. (2) Seminar, two hours. Designed for graduate students. Discussion and student presentations of recent work in molecular virology, including viral gene expression and function. S/U grading.

C274. Advanced Topics in Molecular Parasitology. (2) Lecture, two hours. Requisites: Life Sciences 3, 4. Examination of recent advances in molecular biology of parasites and host/parasite relationship. Specific topics include parasite development, antigenic variation in trypanosomes, RNA editing, prospects for parasitic vaccines. Concurrently scheduled with course C174. Letter grading.

296. Seminar: Research Topics in Microbiology, Immunology, and Molecular Genetics. (1 to 4) Seminar, two hours; research group meeting, one hour. Limited to departmental graduate students. Advanced study and analysis of current topics in microbiology, immunology, and molecular genetics. Discussion of current research and literature in research specialty of faculty member teaching course. S/U grading.

298. Current Topics in Microbiology, Immunology, and Molecular Genetics. (2) Seminar, two hours. Strongly recommended corequisite: course 261. Presentation of student oral critiques and participation in discussions on assigned topics. S/U grading.

375. Teaching Apprentice Practicum. (1 to 4) Seminar, to be arranged. Preparation: apprentice personnel employment as teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of regular faculty member responsible for curriculum and instruction at UCLA. May be repeated for credit. S/U grading.

495. Preparation for Teaching Microbiology in Higher Education. (2) Seminar/discussion/laboratory, two hours. Designed for graduate students. Study of problems and methodologies in teaching microbiology, including workshops, seminars, apprentice teaching, and peer observation. S/U or letter grading.

596. Directed Individual Research. (2 to 12) Tutorial, to be arranged. S/U grading.

598. Research for M.S. Thesis. (2 to 12) Tutorial, to be arranged. S/U grading.

599. Research for Ph.D. Dissertation. (2 to 12) Tutorial, to be arranged. S/U grading.

     
 
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