CM133. Principles, Practices, and Policies in Biotechnology (2 units). (Same as Biological Chemistry CM133, Biomedical Physics CM133, Chemical Engineering CM133, Chemistry CM133, Microbiology CM133, and Molecular, Cell, and Developmental Biology CM133.) Lecture, three hours. Designed for juniors/seniors. Life and physical sciences majors and students in the School of Law and Anderson Graduate School of Management may find course useful in their career preparation. Presentation of technologies, regulatory practices, and policies required for product development and review of current opportunities for new technology development. Topics include fermentation processes, pilot and large-scale bioprocess technologies, scaleup strategies, industrial recombinant DNA processes, hybridomas, protein engineering, peptide mimetics and rational drug design, medical and microscopic imaging, and intellectual property issues. Concurrently scheduled with course CM233.
M185A. Immunology (5 units). (Same as Microbiology M185A and Molecular, Cell, and Developmental Biology M185A.) Lecture, three hours; discussion, 90 minutes; outside study, 11.5 hours. Requisites: Life Sciences 3, 4. Recommended requisites or corequisites: Chemistry 153A, 153L, Molecular, Cell, and Developmental Biology 100 or C139 or M140. Not open for credit to students with credit for course M261 or Molecular, Cell, and Developmental Biology C180. Introduction to experimental immunobiology and immunochemistry; cellular and molecular aspects of humoral and cellular immune reactions.
199. Directed Individual Research Studies in Microbiology and Immunology (2 to 8 units). Prerequisites: senior standing, consent of instructor (based on written research proposal). Individual research projects carried out under direction of a professor.
Undergraduates may enroll in some graduate courses with consent of instructor.
201. Microbiology and Immunology (8 units). Lecture/laboratory. Limited to medical students. Study of infectious agents of human disease, with emphasis on host/parasite relationships and immunologic phenomena in immunity and disease, including identification of bacteria, fungi, animal parasites, and viruses, and principles of prevention, treatment, and laboratory diagnosis.
202A. Fundamentals of Immunology (2 units). Prerequisite: consent of instructor. Introduction to experimental immunobiology and immunochemistry; cellular and molecular aspects of humoral and cell-mediated immune functions.
202B. Medical Bacteriology (2 units). Prerequisite: consent of instructor. Characteristics of bacteria rickettsiae and chlamydiae associated with diseases of humans; host/parasite interactions and immunity; identification and laboratory diagnosis; principles of prevention and treatment; introduction to microbial genetics as it pertains to pathogenicity.
202C. Medical Virology (2 units). Prerequisite: consent of instructor. Biological properties of animal viruses; replication; methods of detection; interactions with host cells and multicellular hosts, introduction to tumor viruses.
202D. Medical Mycology and Parasitology (2 units). Prerequisite: consent of instructor. Morphology, physiology, and pathogenicity of fungi which cause human and animal diseases. Study of morphology, biology, host/parasite relationship, public health problems, and control of protozoa, helminths, and arthropods parasitic in and on humans and animals.
M208. Molecular Biology of Animal Viruses. (Formerly numbered 208.) (Same as Molecular, Cell, and Developmental Biology CM279.) Lecture, three hours. Preparation: courses in general biochemistry and general microbiology, including virology. Recommended for advanced undergraduate students with a major in public health, biology, or microbiology and for graduate students with interest in any field of biology or chemistry. Overview of animal viruses, including viral structure, virus cell interaction, virus replication, and viral oncogenesis. Special emphasis on understanding the molecular mechanism involved in control and regulation of replication, transcription, and translation of viral genome and its complex interaction with host.
M215. Interdepartmental Course: Tropical Medicine (2 units). (Same as Medicine M215, Pathology M215, and Pediatrics M215.) Lecture, two and one-half hours. Prerequisites: basic courses in microbiology and parasitology of infectious diseases in School of Medicine or Public Health. Study of current knowledge about diseases prevalent in tropical areas of the world. Major emphasis on infectious diseases, with coverage of problems in nutrition and exotic noninfectious diseases. Syllabus supplements topics covered in classroom. S/U grading.
M223. Membrane Research Seminar (2 units). (Same as Microbiology M223.) Prerequisite: consent of instructor. Critical discussions of current literature in membrane research, with emphasis on relationship between structure and function in lipid bilayers. May be repeated for credit.
M226A-M226B. Principles of Microbial Pathogenesis. (Same as Microbiology M226A-M226B and Molecular, Cell, and Developmental Biology M226A-M226B.) Lecture, one hour; discussion, three hours. Requisites: courses 202A, 202B, 202C, 202D. Lecture/discussion format designed to analyze basic pathogenesis of infections. Emphasis on molecular and cellular approaches to understand host-microbial interaction. M226A. Bacterial and Mycotic Infections; M226B. Parasitic and Viral Infections.
M227. Molecular Genetics of Bacteria and Phage. (Same as Chemistry M227, Microbiology M227, and Molecular, Cell, and Developmental Biology CM207.) Lecture, three hours; discussion, one hour. Requisite: Biological Chemistry CM253 or Chemistry CM253. Molecular and cellular biology of bacteria and bacteriophages.
M229. Cellular Biology of Host/Pathogen Interactions (6 units). (Same as Microbiology M229 and Molecular, Cell, and Developmental Biology M226A-M226B.) Lecture, four hours; discussion, 90 minutes. Requisite: Biological Chemistry CM253. Molecular and cellular biology of pathogens, eukaryotic host cells, and interaction between pathogens and hosts.
CM233. Principles, Practices, and Policies in Biotechnology (2 units). (Formerly numbered M233.) (Same as Biological Chemistry CM233, Biomedical Physics CM233, Chemical Engineering CM233, Chemistry CM233, Microbiology CM233, and Molecular, Cell, and Developmental Biology CM233.) Lecture, three hours. Designed for graduate students. Life and physical sciences majors and students in the School of Law and Anderson Graduate School of Management may find course useful in their career preparation. Presentation of technologies, regulatory practices, and policies required for product development and review of current opportunities for new technology development. Topics include fermentation processes, pilot and large-scale bioprocess technologies, scaleup strategies, industrial recombinant DNA processes, hybridomas, protein engineering, peptide mimetics and rational drug design, medical and microscopic imaging, and intellectual property issues. Concurrently scheduled with course CM133. S/U or letter grading.
M234. Ethics and Accountability in Biomedical Research (2 units). (Same as Microbiology M234.) Designed for graduate students. Responsibilities and ethical conduct of investigators in research, data management, mentorship, grant applications, and publications. Responsibilities to peers, sponsoring institutions, and society. Conflicts of interest, disclosure, animal subject welfare, human subject protection, and areas in which investigational goals and certain societal values may conflict. S/U grading.
M241. Use of the Computer in Biology (2 units). (Same as Molecular, Cell, and Developmental Biology M201.) Lecture, two hours; laboratory, one hour. Introduction to use of IBM PC microcomputer and VAX minicomputer in biological research. S/U grading.
M246. Computer Analysis of Genetic Organization. (Same as Microbiology M246 and Molecular, Cell, and Developmental Biology M246.) Lecture, two hours; laboratory, six hours. Requisite: Life Sciences 4 or Microbiology C159. Lectures and laboratory instruction in contemporary procedures for analysis of nucleic acid and protein sequence data with the computer. No prior computer experience necessary; students gain both general and specialized facility with IBM PC and Digital VAX computers.
250. Cell and Molecular Biology. Lectures and student seminar presentations. Review of selected current topics in molecular and cellular biology. Topics include recent experimental results on organization, expression, and regulation of genes in eukaryotic cells. S/U or letter grading.
M252. Seminar: Microbial Pathogenesis (2 units). (Same as Microbiology M252.) Prerequisite: consent of instructor. Limited to 10 students. Student presentations and critical discussion of current literature on various aspects of microbial pathogenesis. May be repeated for credit. S/U or letter grading.
M256. Seminar: Viral Oncology (2 units). (Same as Pathology M256.) Advanced research seminar designed to consider current developments in the field. Selection of current subjects and publications dealing with tumor viruses, oncogenesis, development, and cellular regulation.
M260. Immunology Forum (2 units). (Same as Microbiology M260.) Prerequisite: course M185A. Broad range of current topics in immunology presented and discussed at advanced frontier level. Continuing UCLA-wide, general graduate-level seminar involving faculty, postdoctoral immunologists, and graduate students from diverse departments. S/U grading.
M261. Molecular and Cellular Immunology (6 units). (Same as Microbiology M261 and Molecular, Cell, and Developmental Biology CM261.) Lecture, four and one-half hours; discussion, 90 minutes. Requisite: Biological Chemistry CM253. Comprehensive course for graduate students and selected undergraduates covering fundamentals and recent advances in molecular and cellular immunology. Lectures supplemented with discussion section focusing on reading and analysis of primary research articles. Oral presentation required. S/U or letter grading.
M262A. Seminar: Current Topics in Immunobiology of Cancer (2 units). (Same as Microbiology M262A.) Review of recent literature in immunology, biology, and biochemistry of cancer, with emphasis on fundamental studies involving cell-mediated immunity, humoral response, tumor specific antigens, and new techniques. Discussion of reports on scientific meetings. May be repeated for credit. S/U or letter grading.
M262B. Immunology of AIDS (2 units). (Same as Epidemiology M214 and Microbiology M262B.) Lecture, one hour; discussion, one hour. Requisites: courses 202A, 202B, 202C, 202D, M258B. Lecture and student discussion of assigned publications. Topics include specific anti-HIV immune responses, activation of immune system by HIV, and basic mechanisms that underlie HIV-induced immunodeficiency. S/U or letter grading.
M262D. Selected Topics in Immunology (2 units). (Same as Microbiology M262D.) Prerequisite: consent of instructor. Student participation in discussions related to various topics in immunology. May be repeated for credit. S/U or letter grading.
M263. Molecular and Cellular Immunology Seminar (2 units). (Same as Microbiology M263.) Prerequisite: consent of instructor. Critical discussions of current literature in T and B cell immunology, with emphasis on molecular mechanisms.
270. Immunology in Disease (2 units). Lecture, one hour; discussion, one hour. Prerequisite: basic immunology. Introduction to role of immune processes in disease for students with prior knowledge of basic immunology. Topics include immunodeficiency, immediate hypersensitivity reactions, autoimmune disease, and immune complex-mediated diseases, together with transplantation immunology, tumor immunology (re role of immunity in infection). Students prepare a 20- to 30-minute presentation on a selected topic.
271. Immunology Overview (2 units). Lecture, two hours; discussion, one hour. Designed for graduate students. Identification of major components of immune system, their modes of active maturation and regulation, cytokine signaling systems, principal effector mechanisms, and immune contributions to autoimmunity and hypersensitivity.
274. Interactions of Immune System and Nervous System (2 units). Lecture, one hour; discussion, one hour. Prerequisites: graduate or postdoctoral standing in immunology, behavioral sciences, or neurosciences, consent of instructor. Limited to 10 students. Study of existing knowledge of interrelationships between central and peripheral nervous system and immune system. Review of research on central nervous system effects on immune function and vice versa, as well as human and animal studies linking stress to immune changes.
M275. Biology of HIV. (Same as Epidemiology M228.) Lecture, three hours. Prerequisites: Biostatistics 100A and Epidemiology 100 or equivalent, two biology courses, consent of instructor. Overview of virologic and immunologic aspects of HIV disease for epidemiology or other health disciplines. Brief discussion of clinical manifestations and biosafety in the laboratory.
M285. Intermediate Immunology. (Formerly numbered M285B.) (Same as Microbiology CM285 and Molecular, Cell, and Developmental Biology CM285.) Lecture, three hours; discussion, one hour. Requisites: course M185A, Molecular, Cell, and Developmental Biology C180. Recommended corequisite: Chemistry 153B. In-depth exploration of topics introduced in course M185A.
M293. Major Concepts in Oncology. (Same as Oral Biology M293 and Pathology M293.) Lecture, three hours. Prerequisite: graduate standing or consent of instructor. Designed for graduate students contemplating research in oncology. Topics include cancer pathophysiology, genetics, membranes, macromolecular synthesis and control, cell cycle, growth control; physical, chemical, and viral oncogenesis, epidemiology of cancer; tumor immunology; principles of cancer surgery, radiation therapy, and chemotherapy. S/U or letter grading.
M294. Molecular Basis of Cancer. (Same as Pathology M294.) Lecture, three hours. Requisites: course M229, Biological Chemistry CM253, CM267, Neurobiology M209A. Fundamental biological, genetic, and molecular process involved in genesis and growth of cancer cells and diagnosis, characterization, and treatment of cancer.
596. Directed Individual Study or Research (2 to 8 units). Laboratory, to be arranged. Prerequisite: consent of graduate adviser. S/U grading.
597. Preparation for Ph.D. Qualifying Examinations (2 to 6 units).
599. Research for and Preparation of Ph.D. Dissertation (2 to 12 units). Research on an original problem in the field of microbiology and immunology to be selected by graduate student with advice of adviser. Fields of study may be in bacteriology, immunology, mycology, parasitology, virology, tumor biology, or cell biology.